Film-facilitated formation of ferrocenecarboxylic acid-embedded metal-organic framework nanoparticles for sonodynamic osteosarcoma treatment

Sonodynamic therapy (SDT) has stronger penetrating ability compared with phototherapy due to the replacement of excitant from near-infrared light ultrasound. The effective combination low-intensity ultrasound and sonosensitizers allows SDT penetrate deep tissue for treatment solid tumors. In this research, hybrid metal-organic framework (MOF) nanoparticles (FcCOOH-ZnTCPP, FcCOOH: ferrocenecarboxylic acid, TCPP: tetra(4-carboxyphenyl)porphyrin) are synthesized by a simple film technology, demonstrating outstanding acoustic response characteristics. FcCOOH is directly embedded in during formation process FcCOOH-ZnTCPP, where catalyzes excess hydrogen peroxide tumor microenvironment oxygen increasing effect. Hybrid MOF good biocompatibility internalization cells present enhanced therapeutic effect osteosarcoma on account synergistic contributions ZnTCPP FcCOOH. This FcCOOH-ZnTCPP system may pave new way precise efficient inhibition.